Self-activated in vivo therapeutic cascade of erythrocyte membrane-cloaked iron-mineralized enzymes
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منابع مشابه
Lipid-insertion enables targeting functionalization of erythrocyte membrane-cloaked nanoparticles.
RBC membrane-cloaked polymeric nanoparticles represent an emerging nanocarrier platform with extended circulation in vivo. A lipid-insertion method is employed to functionalize these nanoparticles without the need for direct chemical conjugation. Insertion of both folate and the nucleolin-targeting aptamer AS1411 shows receptor-specific targeting against model cancer cell lines.
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Abnormal deposits of free iron are found on the cytoplasmic surface of red blood cell (RBC) membranes in beta-thalassemia. To test the hypothesis that this is of importance to RBC pathobiology, we administered the iron chelator deferiprone (L1) intraperitoneally to beta-thalassemic mice for 4 wk and then studied RBC survival and membrane characteristics. L1 therapy decreased membrane free iron ...
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AIM Polymeric nanoparticles (NPs) cloaked by red blood cell membrane (RBCm) confer the combined advantage of both long circulation lifetime and controlled drug release. The authors carried out studies to gain a better understanding of the drug loading, drug-release kinetics and cell-based efficacy of RBCm-cloaked NPs. MATERIALS & METHODS Two strategies for loading doxorubicin into the RBCm-cl...
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Fraker, P. J. & Speck, J. C., Jr. (1978) Biochem. Biophys. Res. Snary, D., Goodfellow, P., Hayman, M. J., Bodmer, W. F. & Commun. 80,849-857 Hubbard, A. L. & Cohn, 2. A. (1976) in Biochemical Analysis of Okayama, H., Ueda, K. & Hayaishi, 0. (1978) Proc. Natl. Acad. Sci. Membranes (Maddy, A. H., ed.), pp. 427-501, Chapman and Hall, London Zittle, C. A. (1951) Adv. Enzymol. Relat. Areas Mol. Biol...
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By Stanley L. Schrier T HE PAST TWENTY YEARS have seen a remarkable growth in information concerning the metabolism of the human erythrocyte. It became apparent that, depending on the method of preparation, some of the enzymes of the human erythrocyte can be recovered partially or totally in an operationally defined membrane fraction. Therefore, there now exists a substantial body of informatio...
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ژورنال
عنوان ژورنال: Theranostics
سال: 2020
ISSN: 1838-7640
DOI: 10.7150/thno.39621